This was the fifth consecutive ALCS appearance for the Astros, which was the first time a team had accomplished this feat since the 1991–1999 Atlanta Braves and the first in the AL since the 1971–1975 Oakland Athletics.

[9] The only other postseason meeting between the Astros and Red Sox came during the 2017 American League Division Series, which was won by Houston in four games.

[11] The Astros' ace starting pitcher Lance McCullers Jr. was left off the ALCS roster due to a forearm injury.

Framber Valdez of the Astros was matched up against Chris Sale of the Red Sox, but the game would soon turn into a bullpen affair.

[13] A one-out walk by Xander Bogaerts, followed by a single and an error, gave Boston a 2–1 lead, and Hunter Renfroe then doubled to make it a 3–1 game.

[14] Carlos Correa put Houston ahead, 4–3, with a solo home run in the bottom of the seventh off of Hansel Robles.

After the Astros loaded the bases with none out in the bottom of the eighth off of Red Sox reliever Hirokazu Sawamura, an Altuve sacrifice fly gave Houston a 5–3 lead.

Boston got a run back to start the ninth, as Hernández homered off of Houston closer Ryan Pressly.

Yuli Gurriel and Jason Castro each hit solo home runs in the bottom of the ninth, making it 9–5, the final score.

Boston added three runs in the bottom of the third, including a two-run homer by Christian Arroyo, extending the Red Sox' lead to 9–0.

Astros right fielder Kyle Tucker hit a three-run homer with two out in the top of the fourth, making it a 9–3 game.

Rafael Devers hit a solo home run in the bottom of the eighth, extending the lead to 12–3, the final score.

In the bottom of the first, Rafael Devers walked with two outs, then Xander Bogaerts homered to give the Red Sox a 2–1 lead.

Christian Arroyo hit a one-out triple in the bottom of the fourth, but the Red Sox were unable to score him.

Nate Eovaldi came in to pitch the top of the ninth, and Carlos Correa led off with a double over Hunter Renfroe in right field.

With two outs and after a controversial non-strike three call by home plate umpire Laz Díaz, Jason Castro singled to drive in Correa and give the Astros a 3–2 lead.

Houston took a 1–0 lead on a solo home run by Yordan Alvarez in the top of the second inning, to the opposite field over the Green Monster.

[33] Sale took the loss, having pitched 5+1⁄3 innings while allowing four runs (two earned) on three hits and two walks while striking out seven batters.

[32] He became the seventh visiting pitcher to go at least eight innings while allowing one run or fewer at Fenway Park in the postseason, and the first since Charles Nagy in the 1998 ALDS.

The Astros took a 1–0 lead in the bottom of the first; with two outs, Alex Bregman singled then was driven in on a double by Yordan Alvarez that hit off the glove of Red Sox center fielder Kiké Hernández.

García held the Red Sox hitless through five innings; he left in the top of the sixth after allowing a two-out triple to Hernández.

After Carlos Correa was hit by a pitch from Tanner Houck, Kyle Tucker grounded into a double play, scoring Alvarez and giving Houston a 2–0 lead.

Alvarez collected his fourth hit of the game in the bottom of the eighth, singling to give the Astros runners at first and second with one out.