The 2021 Belarusian Premier League was the 31st season of top-tier football in Belarus.
Shakhtyor Soligorsk were the defending champions, having won their second league title last year.
Shakhtyor Soligorsk won their third Belarusian Premier League title.
In the winter 2020/21, Gorodeya (who finished 13th last year) dissolved and left a Premier League spot vacant.
Smorgon (6th-placed team of last year's First League season, promoted after an eleven-year absence) were admitted to fill the vacancy, after Krumkachy Minsk (First League 3rd-placed team) were denied Premier League license, and another two clubs (Arsenal Dzerzhinsk and Lokomotiv Gomel) rejected the opportunity due to insufficient financing.