The matches took place from 2 to 6 July 2021, the week before the start of the Gold Cup group stage, at DRV PNK Stadium, Fort Lauderdale, Florida in the United States.

The four first round winners would face the four third-placed teams of Nations League A, played as two-legged ties.

The qualifying draw took place on 11 December 2019, 19:00 EST (UTC−5), in Miami, Florida, United States.

[9][10] The draw results were as follows: On 13 March 2020, CONCACAF suspended all upcoming competitions scheduled to take place over the next 30 days due to the COVID-19 pandemic, with the new dates of the matches to be confirmed later.

[11] On 3 April 2020, CONCACAF announced the suspension of the June qualifiers, with the new dates of the matches to be confirmed at a later time.

[14] The following was the composition of the draw pots (August 2020 CONCACAF Rankings show in parentheses):[15] The match schedule was announced on 13 May 2021.

As a result, CONCACAF decided to replace them with the next highest-ranked team from qualification (based on wins, draws and goal difference), Guatemala.