The tournament organizers did not agree with this decision and on 3 August 2021 they communicated to CONMEBOL that Chile would not host the championship.

[8] After their elimination in the quarter-finals, Kindermann ended their partnership with Avaí and the team was disbanded in November 2021.

[25] The draw for the tournament was held on 24 September 2021, 12:00 PYT (UTC−4), at the CONMEBOL Convention Center in Luque, Paraguay.

The four additional teams from associations with the best historical performance (Brazil 3, Chile 2, Colombia 2 and Paraguay 3) were seeded into Pot 4.

[11] Daniela Arias (Santa Fe) was inscribed on the tournament but she did not play due to injury.

[30] Final MVP Award: Gabi Zanotti (Corinthians) Assistant referees:[31] Mariana de Almeida (Argentina) Daiana Milone (Argentina) Fourth official: Anahí Fernández (Uruguay) Video assistant referee: Salomé di Iorio (Argentina) Assistant video assistant referees: María Belén Carvajal (Chile) Loreto Toloza (Chile) Match rules As per statistical convention in football, matches decided in extra time were counted as wins and losses, while matches decided by penalty shoot-out were counted as draws.

The 2021 Copa Libertadores Femenina team was a squad consisting of the eleven most impressive players at the tournament.