[1] The winners of the FAI Cup earns automatic qualification for the 2022–23 UEFA Europa Conference League.
Six teams received byes into the first round of the competition: Bangor GG F.C., Malahide United, Liffey Wanderers, St. Kevin's Boys, Usher Celtic and College Corinthians[2] The draw for the first round took place on 13 July 2021.
Bracketed number denotes which tier team currently plays in The draw for the second round was made on 27 July 2021 at 6:30pm.
[4] All ties were set to be played the week ending Sunday 29 August 2021.
All ties were set to be played the week ending Sunday 19 September 2021.