[1] Hasaacas Ladies were crowned champions after beating Ampem Darkoa FC 2–0 in the final.
[8][1] At the round of 32 stage, the clubs were grouped on zonal basis to reduce travelling time, cost and facilitate more local derbies.
[17] [17][1][2] The draw of the quarter final was held on 4 June 2021 in the studio of StarTimes Adepa channel 247 and Max TV.
[18] Four matches were expected to be played at this stage and the balloting was done having teams in the Northern and Southern zone put together in one pot.
The round featured eight teams from the Women's Premier League (level 1).The draw for the semi-finals was held on 21 March 2021, in the studio of StarTimes Adepa channel 247 and Max TV.