The 2021 Lithuanian Football Cup was a single elimination association football tournament which began on 22 May 2021 and ended on 23 October 2021.
[1] The winner of the competition earned a spot in the second qualifying round of the 2022–23 UEFA Europa Conference League.
Same as last year, lower league teams were not invited in order to shorten the competition due to the ongoing COVID-19 pandemic.
The A lyga teams entered the tournament from the first round this year.
[1] Two random teams received a "bye" to the second round.