It began on 3 August 2021 and ended with the final on 31 October 2021.
Vålerenga won the competition for the second year in a row after beating Sandviken in the final.
[2] All Toppserien teams received a bye in this round.
[6] [3] The draw for the semi-finals was made on 13 September 2021.
[7] The semi-finals were played between the top four teams in the 2021 Toppserien.