The 2021 Tour de la Provence was a road cycling stage race that took place between 11 and 14 February 2021 in the French region of Provence.

The race is rated as a 2.Pro event as part of the 2021 UCI Europe Tour and the 2021 UCI ProSeries, and was the sixth edition of the Tour de la Provence cycling race.

[1] Fourteen of the nineteen UCI WorldTeams, four UCI ProTeams, and two UCI Continental teams made up the twenty teams that participated in the race.

Each team entered a roster of seven riders, for a total of 139 starters, after Serbian rider Dušan Rajović of Delko was a last-minute non-starter.

133 riders finished the race.