The 2021 Vuelta a Burgos was a men's road cycling stage race that took place from 3 to 7 August 2021 in the Spanish province of Burgos.

It was the 43rd edition of the Vuelta a Burgos, and was rated as a 2.Pro event as part of the 2021 UCI Europe Tour and the 2021 UCI ProSeries calendars.

[1][2] Thirteen of the nineteen UCI WorldTeams are joined by eight UCI ProTeams to make up the twenty-one teams that participated in the race.

[3][4] Bora–Hansgrohe and UAE Team Emirates, with six riders each, were the only teams not to enter a full squad of seven riders; in total, 146 riders started the race.

127 riders finished.