In the top of the third, Eddie Rosario singled, followed by a two-run home run from Adam Duvall, making it 5–0 Braves and driving Valdez from the game after 52 pitches.

[23] Morton left in the bottom of the third inning with an injury; X-rays later revealed a fibular fracture in his right leg, causing him to miss the remainder of the series.

In the bottom of the fourth inning, Tucker hit a one-out double, advanced to third when Gurriel singled with one out, and scored on a fielder's choice, making it 5–1.

In the top of the eighth, after three scoreless innings, Dansby Swanson walked, advanced to third on a single by Soler, and scored on a sacrifice fly by Freeman, extending Atlanta's lead to 6–1.

[27] Giavanni Walker, a petty officer first class in the United States Navy, sang the national anthem, and Hall of Famer Jeff Bagwell threw the ceremonial first pitch.

[28] In the bottom of the first inning, Jose Altuve doubled, advanced to third on a flyout by Michael Brantley, and scored on a sacrifice fly by Alex Bregman, giving Houston a 1–0 lead.

In the top of the second, Atlanta tied the game, 1–1, via a solo home run to left field by Travis d'Arnaud, coming on a full count with two outs.

[30] With two outs in the top of the fifth inning, Freddie Freeman delivered an RBI single to left, scoring d'Arnaud and cutting the Astros' lead to 5–2.

Tyler Matzek started the eighth for the Braves and allowed a bloop single to Aledmys Díaz, who was replaced by José Siri as a pinch-runner.

Prior to the game, the Astros replaced backup catcher Jason Castro on their roster with Garrett Stubbs, due to COVID-19 protocols.

Houston reliever Phil Maton entered, struck out Ozzie Albies, and allowed a hit to Austin Riley that scored a run, cutting the lead to 2–1.

Back-to-back solo home runs by Dansby Swanson and Jorge Soler off of Cristian Javier with one out in the bottom of the seventh put Atlanta ahead, 3–2.

[49] Hall of Fame inductee Greg Maddux threw out the ceremonial first pitch, and Lauren Alaina performed the national anthem.

The Astros tied the game at 5–5 in the fifth inning when Maldonado drew a walk with the bases loaded, and then scored two more runs on a single by Marwin González to take a 7–5 lead.

[55] A "Rally Nun"[d] threw out the ceremonial first pitch, and country music artist Carly Pearce sang the national anthem.

In the top of the fifth, a two-run home run by Dansby Swanson followed by a walk then a two-out double by Freddie Freeman extended Atlanta's lead to 6–0.

Tyler Matzek entered in relief in the bottom of the seventh; Fried allowed no runs on four hits while striking out six batters and walking none in six innings.

He allowed a leadoff single to Michael Brantley and retired the next three batters, the last out being a Yuli Gurriel infield grounder fielded by Swanson, who threw to Freeman, giving the Braves the title.

For the 22nd straight year, the World Series was televised in the United States by Fox (including the local affiliates WAGA-TV in Atlanta and KRIV in Houston).

Joe Buck called the games as a play-by-play announcer, along with Hall of Famer and former Braves pitcher John Smoltz as color analyst and Ken Rosenthal and Tom Verducci as field reporters.

[65] Kevin Burkhardt hosted the pregame and postgame shows, joined by analysts Frank Thomas, Alex Rodriguez, David Ortiz, and Dontrelle Willis.

MLB International fed the series to broadcasters outside the United States, with Scott Braun providing play-by-play and Dan Plesac as color commentator.

[74] For the 24th consecutive year, ESPN Radio aired the series in the United States, led by Dan Shulman on play-by-play with Jessica Mendoza and Eduardo Pérez as color analysts; Kevin Winter hosted the pregame coverage with analyst Chris Singleton and reporters Buster Olney and Marly Rivera, while Olney provided in-game reports and conducted postgame interviews.

Those struggles however disappeared for Smith in the postseason as the veteran reliever worked 11 consecutive scoreless innings in October allowing only five hits, three walks, and eight strikeouts with six saves.

[82] The Braves celebrated their championship with a parade on November 5, with fitting nods to Henry "Hank" Aaron, the franchise legend who died in January at the age of 86.

Once the parade reached Cumberland and Truist Park, the crowd was addressed by Henry's widow, Billye Aaron, in a fitting tribute to the slugger.

[86] Following the conclusion of the season, the Astros lost five players to free agency: Carlos Correa to the Minnesota Twins, Zack Greinke to the Kansas City Royals, Marwin González to the New York Yankees, Kendall Graveman to the Chicago White Sox, and Brooks Raley to the Tampa Bay Rays.

[87] Justin Verlander was the lone free agent to re-sign with the Astros, returning on a two-year deal with a player option in the second year after missing all of the 2021 season.

[89][90] The Astros repeated as American League West champions in 2022, their sixth consecutive postseason appearance and fifth division title in six seasons.

[92] Fox would promote number two play-by-play baseball announcer Joe Davis to replace Buck's spot for the regular season, All-Star, and postseason games.