Gaël Monfils defeated Karen Khachanov in the final, 6–4, 6–4 to win the men's singles tennis title at the 2022 Adelaide International 1.

[1] Andrey Rublev was the reigning champion from when the tournament was last held in 2020,[2] but chose not to participate this year.

[3] Corentin Moutet's default marks the 19th consecutive year since 2004 with at least one default between the ATP and the Challenger tours.

[citation needed] The top four seeds received a bye into the second round.