Thanasi Kokkinakis defeated Arthur Rinderknech in the final, 6–7(6–8), 7–6(7–5), 6–3 to win the men's singles title at the 2022 Adelaide International 2.

It was his first ATP Tour title, and he won it in his hometown of Adelaide.

Kokkinakis saved a match point against Marin Čilić in the semifinals.

This was the second edition of the Adelaide International for 2022.

[1] The top four seeds received a bye into the second round.