The 2022 Ambato La Gran Ciudad was a professional tennis tournament played on clay courts.

It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place in Ambato, Ecuador between 17 and 23 October 2022.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: