The 2022 Challenger Coquimbo II was a professional tennis tournament played on clay courts.

It was part of the 2022 ATP Challenger Tour.

It took place in Coquimbo, Chile between 17 and 23 October 2022.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: