The 2022 Uruguay Open was a professional tennis tournament played on red clay courts in Montevideo.

It was the 17th edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between 7 and 13 November 2022.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: