The 2022 Lima Challenger II was a professional tennis tournament played on clay courts.

It was the 18th edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place in Lima, Peru between 24 and 30 October 2022.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as a special exempt: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: The following players received entry as lucky losers: