Ninety-four teams from the División Profesional and regional leagues were slated to take part in the competition, which started on 21 April with its regional preliminary stages and was scheduled to end on 3 November 2022.
[3] The competition was cancelled by the FBF on 18 July 2022, prior to the start of the national stage, after 28 out of the 32 teams that qualified failed to fully comply with the established requirements.
[2] For the national stage, which was not played, the 16 Primera División clubs would be drawn against a rival from the División Aficionados (Copa Simón Bolívar or regional league) into 16 double-legged ties in which the lower-tier team would host the first leg, with the 16 winners advancing to the round of 16.
[5] The subsequent rounds (round of 16, quarter-finals, and semi-finals) would also be played as double-legged ties, while the final would be played as a single game on neutral ground.
Teams from the Bolivian Football Regional Leagues took part in various department-based preliminary rounds to win one of the 9 places in the national stage (round of 32).