[6][7] Tied 2–2 on aggregate, Deportivo Táchira won on penalties and advanced to the quarter-finals (Match S1).
Tied 2–2 on aggregate, Atlético Goianiense won on penalties and advanced to the quarter-finals (Match S2).
[19][20] Independiente del Valle won 5–1 on aggregate and advanced to the semi-finals (Match F1).
Tied 2–2 on aggregate, São Paulo won on penalties and advanced to the semi-finals (Match F2).
The final was played on 1 October 2022 at Estadio Mario Alberto Kempes in Córdoba.