[2] The draw for the qualifying stages was held on 20 December 2021, 12:00 PYST (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.
If tied on aggregate, extra time is not played, and a penalty shoot-out is used to determine the winner (Regulations Article 2.4.3).
Tied 3–3 on aggregate, América Mineiro won on penalties and advanced to the third stage (Match G4).
[29][30] Tied 3–3 on aggregate, Olimpia won on penalties and advanced to the group stage.
Tied 0–0 on aggregate, América Mineiro won on penalties and advanced to the group stage.