[2] After the end of the Copa de la Liga, it will start the 2022 Primera División season, in order to complete the schedule prior to the 2022 FIFA World Cup.
Boca Juniors won their second title after they defeated Tigre 3–0 in the final.
As champions, Boca Juniors qualified for the 2023 Copa Libertadores and the 2022 Trofeo de Campeones.
[3] As Boca Juniors qualified for the Copa Libertadores group stage by winning the 2022 Argentine Primera División, Racing (best team in the 2022 aggregate table) earned the Copa de la Liga Profesional berth.
[4] The draw for the group stage was held on 11 January 2022, 15:00, at the Hilton Hotel in Buenos Aires.