Rafael Nadal defeated Casper Ruud in the final, 6–3, 6–3, 6–0 to win the men's singles tennis title at the 2022 French Open.

One week later, when points from the previous year's tournament were dropped,[12] Medvedev reclaimed the top ranking, while Zverev reached world No.

Additionally, as Roger Federer did not enter the tournament, he fell outside of the top 50 in the ATP rankings for the first time since 5 June 2000.

[16] Holger Rune was the first Danish man to reach a major singles quarterfinal in the Open Era.

[18][19][20] Camilo Ugo Carabelli and Aslan Karatsev became the first players to contest this tiebreak in the main draw in their first-round match.

† This column shows either (a) the player's points from tournaments held during the week of 24 May 2021 (Belgrade 2 and Parma) or (b) his 19th best result (in brackets).