The regular season began on March 25 and was concluded on September 18, 2022.
Columbus Crew 2 defeated St. Louis City 2 4–1 in the inaugural MLS Next Pro Cup final on October 8.
[1][2] Note: All teams use Adidas as universal kit manufacturer.
The regular season will feature 24 matches in a mostly regionalized schedule.
Most Valuable Player: Marco Micaletto (Columbus Crew 2)