Pablo Carreño Busta defeated Hubert Hurkacz in the final, 3–6, 6–3, 6–3 to win the men's singles tennis title at the 2022 Canadian Open.

[1] Daniil Medvedev was the defending champion,[2] but lost in the second round to Nick Kyrgios.

[3] For the first time since 1999 Indian Wells, the top three seeds at a Masters 1000 tournament were defeated in their opening matches.

[4] Jannik Sinner's loss in the third round also guaranteed a maiden Masters 1000 finalist in the bottom half of the draw, from which Carreño Busta emerged.

Points for the 2021 tournament were not mandatory and are included in the table below only if they counted towards the player's ranking as of August 8, 2022.