The 2022 Open Sud de France was a tennis tournament played on indoor hard courts.

It was the 35th edition of the event, and part of the ATP Tour 250 series of the 2022 ATP Tour.

Sixth-seeded Alexander Bublik won the singles title.

[1] This was Bublik's maiden ATP Tour singles title.

*per team The following players received wildcards into the singles main draw : The following player received entry using a protected ranking into the singles main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following pair received entry using a protected ranking into the doubles main draw: