The 2022 Open delle Puglie was a professional tennis tournament played on outdoor clay courts.

It was the first edition of the tournament and part of the 2022 WTA 125 tournaments, offering a total of $115,000 in prize money.

It took place at the Circolo del Tennis at the Via Martinez in Bari, Italy between 5 and 11 September 2022.

[1][2] The following players received a wildcard into the singles main draw: The following players received entry into the main draw through qualification: The following players entered the main draw as lucky losers: The following pair received a wildcard into the doubles main draw: