Defending champions Rajeev Ram and Joe Salisbury defeated Wesley Koolhof and Neal Skupski in the final, 7–6(7–4), 7–5 to win the men's doubles tennis title at the 2022 US Open.

[3] Michael Venus, Horacio Zeballos, Mate Pavić, Jean-Julien Rojer, and Skupski were also in contention for the top ranking.

2 and six-time doubles major champion Bruno Soares; partnering with Jamie Murray, he lost in the second round to Hugo Nys and Jan Zieliński.

[4] This is the first edition of US Open to feature a 10-point tie-break, when the score reaches six games all in the deciding set.

[5] Marcelo Demoliner and João Sousa defeated Marcel Granollers and Zeballos in the first round in the first main-draw 10-point tie-break at US Open.