Characteristic features of the large subunit, shown below in the "Crown View", include the central protuberance (CP) and the two stalks, which are named according to their bacterial protein components (L1 stalk on the left as seen from the subunit interface and L7/L12 on the right).
There are three binding sites for tRNA, the A-site, P-site and E-site (see article on protein translation for details).
Proteins which have homologs in eukaryotes, archaea and bacteria are shown as blue ribbons.
The eukaryote-specific extensions, ranging from a few residues or loops to very long alpha helices and additional domains, are highlighted in red.
For instance, proteins have been numbered according to their migration properties in gel electrophoresis experiments.