ACE mixture is an historical anaesthetic agent for general anaesthesia.
[1] One doctor described using equal parts alcohol and chloroform in minor operations, but chloroform with Eau de Cologne (which has a high alcohol content) in dental procedures for a more pleasant experience.
Instead, it was later discovered as a mixture of chloroform and alcohol marketed as the bichloride of methylene and even given the formula CH2Cl2.
Ellis proposed an inhaler to blend vapours in exact proportions, however it was impractical, but Gwathmey modified his idea and created a practical apparatus.
Tyrrell created a similar idea called the 'Tyrrell's double-bottle method'.