1T445811459ENSG00000143632ENSMUSG00000031972P68133P68134NM_001100NM_001272041NM_009606NP_001091NP_001258970NP_033736Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.

Actins are highly conserved proteins that are involved in cell motility, structure and integrity.

[7] Skeletal alpha actin expression is induced by stimuli and conditions known to cause muscle formation.

[9] One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene.

[10] SRF may bring a number of other proteins to the promoter of skeletal actin, such as androgen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids.