He played college football for the UConn Huskies and was selected by the Arizona Cardinals in the fifth round of the 2011 NFL draft.

In track & field, Sherman served as the team captain and competed in the sprinting and throwing events.

[6] As a freshman in 2007, Sherman immediately became the starting fullback for the UConn Huskies and was the lead blocker for Donald Brown, the 2008 Big East Offensive Player of the Year.

[8] In his junior and senior seasons, Sherman was elected team captain and was the lead blocker for fellow Massachusetts native, Jordan Todman, who was the 2010 Big East Offensive Player of the Year and an ESPN All-American.

[17] Sherman was traded to the Kansas City Chiefs on May 1, 2013, in exchange for cornerback Javier Arenas.

[18] On October 27, 2013, Sherman caught a touchdown pass from Alex Smith against the Cleveland Browns.

[20] In the Wild Card Round against the Indianapolis Colts, he recorded a five-yard receiving touchdown in the 45–44 loss.

[25] On September 17, 2017, in Week 2 against the Philadelphia Eagles, he recovered a fumble on a Darren Sproles punt return.

[29] In the Chiefs' 2018 season opener against the Los Angeles Chargers, he recorded a 36-yard receiving touchdown in the 38–28 victory.

[30] On March 22, 2019, Sherman signed a one-year $1.02 million contract extension with the Chiefs,[31] and won an NFL championship in Super Bowl LIV with the team.

[39] Sherman and his wife, Jessica, have partnered with the child sponsorship and Christian humanitarian aid organization Compassion International for various initiatives.

He tweeted "The @NFL is making players wear colored wrist bands now based on vaccination status.