One segment of 6.65 miles (10.70 km) runs from Highway 38 in Cotton Plant north to Woodruff County Road 680 (CR 680) at Becton.

[4] The third segment runs 5.98 miles (9.62 km) east from Cross CR 825 at the St. Francis River to Highway 75 at Gieseck.

The route terminates at Highway 284 near Village Creek State Park and Summer Sweet Lake.

[4] Highway 306 begins at Cross CR 825, which runs parallel to the St. Francis River levee.

[5] The road from Hunter east to the St. Francis county line was designated a state highway on April 24, 1963.