The Atchison, Topeka and Santa Fe Passenger and Freight Complex is a nationally recognized historic district located in Fort Madison, Iowa, United States.

The facility currently houses a local history museum, and after renovations a portion of it was converted back to a passenger train depot for Amtrak, which opened on December 15, 2021.

[1] The historic district consists of a former passenger depot (1910) and a former freight station (1934) built by the Atchison, Topeka and Santa Fe Railway.

[5] Fort Madison had become a division and crew change point for Santa Fe routes, and it had a locomotive repair shop and other facilities in town, so an upgraded depot was seen as a necessity.

Adjoining the depot, it too is composed of pressed brick with stone trim, a concrete foundation, and red tile roof.

A fire in the late 1960s or early 1970s destroyed a wooden frame structure that was attached to the building and was used for loading and unloading freight.

As the depot was a crew changing location, the Santa Fe's conductor and brakemen showered and slept in this building.

The city leased the buildings to the North Lee County Historical Society (NLCHS) beginning in 1972 for a local history museum.

[7] Between 2006 and 2021, the City of Fort Madison, BNSF Railway, Amtrak, the Iowa Department of Transportation, the Southeast Iowa Regional Planning Commission, and the NLCHS worked together to restore the old Santa Fe station and create an Amtrak waiting room and ticket office in addition to museum space.

The former Chicago, Burlington and Quincy (CB&Q) Fort Madison station is located immediately to the north of the Santa Fe complex, but it is not part of the historic district.