The valley is located at the southwest border of the Aubrey Cliffs; to the west and southwest, the Yampai Divide and the Seventyfour Plains form flatlands between four bordering mountain ranges at the northwest terminus of the Arizona transition zone.

Route 66 traverses north-east across the south valley terminus region to Grand Canyon Caverns, then mostly west across the Yampai Divide to Peach Springs, Arizona at the beginning of hills, and mountains.

The central valley has two routes that spur northwards from Arizona 66, west of Grand Canyon Caverns.

Paved road, Res Route 18 traverses the northwest at the hillside foothills of the valley and passes Blue Mountain, 6,038 feet (1,840 m), continues northeast through Robbers Roost, Arizona in a section of hills, then meets Res Route 18 at Fraziers Well, Arizona, the north terminus of Aubrey Valley; the valley narrows here between Aubrey Cliffs, east, and hills and mountains to the west.

The Aubrey Cliffs reappear northwest, west-northwest of this point, in the southeast of Prospect Valley.