It was opened on 10 June 2001 and is located on the LGV Méditerranée high-speed line and Avignon-Centre–Avignon TGV railway.

This allows trains not stopping at Avignon to pass through at full speed, but away from passenger platforms.

This station, inaugurated in 2001, was designed by the cabinet of architecture of the SNCF under the direction of Jean-Marie Duthilleul and Jean-François Blassel.

[1] The station is served by the following services:[2][3][4] From Avignon TGV train services depart to major French cities such as: Paris, Lyon, Marseille, Cannes, Nice, Dijon, Strasbourg, Montpellier, Nantes, Rennes and Lille.

Parts of the 2007 film "Mr Bean's Holiday" were shot at the Avignon station.