The hospital offers many areas of expertise, including surgery and trauma, neuroscience, cardiology, acute rehabilitation and obstetrics.

Orlando Health Bayfront Hospital Center for Women and Babies offers full obstetrical services.

Bayflite, the largest hospital-based flight program in the Southeastern United States, was started more than two decades ago[when?]

Bayfront, in its Mound Park Hospital form, was mentioned in the Ian Fleming 007 novel "Live and Let Die".

In October 2012, plans were announced to merge Bayfront Medical Center with Health Management Associates and Shands HealthCare.