[1] The set intentionally resembles a low-budget amateur production for public-access television,[1] with on-screen graphics containing deliberate comedic errors.

[2] Galifianakis maintains a very awkward and often antagonistic demeanor with his guests, asking them bizarre, inappropriate or insulting questions mixed with offhand non-sequiturs.

[3] Episodes often include a segment in which Galifianakis awkwardly interrupts his guests to promote a sponsor's product.

After the network declined to pick up the show, the duo put the short up on the website Funny Or Die, where it made a successful transition to an internet series.

[6] The episode featuring President Barack Obama was timed to encourage Americans to sign up for health insurance at Healthcare.gov.

It featured then-presidential candidate Hillary Clinton and received over 30 million views in its first 24 hours, the highest viewership in FunnyorDie.com's history.

[11] Uncut interviews from the film featuring David Letterman, Paul Rudd, Awkwafina, Benedict Cumberbatch, Brie Larson, Keanu Reeves, Hailee Steinfeld, and Adam Scott were released on the Netflix Is A Joke YouTube channel and FunnyOrDie.com under the title Between Two Ferns with Zach Galifianakis: The Movie, Sorta Uncut Interviews, which was nominated for the 2020 Primetime Emmy Award for Outstanding Short Form Variety Series.