[5] In the Nebraska license plate system, Blaine County is represented by the prefix 86 (it had the 86th-largest number of vehicles registered in the state when the license plate system was established in 1922).

The settlement of Blaine County , like the rest of the Sandhills region, began later than many other Nebraska counties due to its less accessible and perceived less fertile location than other parts of Nebraska.

Ranching, particularly cattle, became the economic mainstay, as the sandy soil was better suited for grazing than for crop cultivation.

[7] As of the 2000 United States Census,[14] there were 583 people, 238 households, and 168 families in the county.

26.90% of all households were made up of individuals, and 13.90% had someone living alone who was 65 years of age or older.

In only four national elections since 1900 has the county selected the Democratic Party candidate, and none since 1936.