In many countries in Europe, such as Germany, Bulgaria, Serbia, Ukraine, Belarus, Russia, Poland, Hungary, Latvia, Romania, Estonia and Lithuania, it is sold as Blend-A-Med, the name of an established German toothpaste acquired by P&G in 1987 (formerly Blendax GmbH).

[1] In France, Spain, Italy, Israel, Sweden, Finland, Colombia, Belgium, the Netherlands, Brazil, the United Kingdom, the Republic of Ireland, Australia, New Zealand, Nigeria, Greece, Uruguay and Argentina, P&G markets similar oral hygiene formulations under the Oral-B brand.

Procter & Gamble paid royalties from use of the patent and thus financed a new dental research institute at this university ("The House that Crest built").

One notable ad campaign from the brand was in the late 1970s and early 1980s, written and produced by Gregory Sinnott and designed by comic book artist Herb Trimpe, where animated ads featured the "Cavity Creeps," a group of grey-colored, rocky humanoid creatures bent on destroying the city of "Toothopolis" (essentially an island city protected by an enormous wall of teeth), with their signature battle cry "We make holes in teeth!"

[17] However, after numerous complaints[18] and a federal class-action lawsuit,[19] which was later dismissed,[20] the mouthwash now contains a label warning consumers of its potential to stain teeth.