Bob and George was a sprite-based webcomic which parodied the fictional universe of Mega Man.

The initial strips were mostly done in GIF format (occasionally using JPEG for more graphic-intensive comics) before converting to PNG in May 2004.

Animated comics are generally used for the annual week-long anniversary parties (usually culminating in a brief animated comic that recaps the events of the past year in a matter of seconds), for especially climactic scenes, and for a series of videos depicting an in-comic event known as "the Cataclysm".

Amongst past story arcs there have been retellings of various Mega Man games (which often play out quite differently from the originals), as well as battles against powerful foes.

Bob and George was originally planned to be a hand-drawn webcomic about the college adventures of the two titular brothers.

Other characters featured in Bob and George include Proto Man, Dr. Light, Roll, and Bass.

Mega Man characters such as Dr. Wily, X, and Zero are featured in Bob and George as villains and adversaries.

Story lines frequently involve breaking the fourth wall, with the strips' author being a regular character.