During his senior season in 2013, Speaks had 118 tackles, 26.5 tackles for loss, nine sacks, 18 quarterback hurries, four forced fumbles, three blocked kicks, five pass breakups and an interception returned for a touchdown.

[7] Speaks was selected by the Kansas City Chiefs in the second round (46th overall) of the 2018 NFL Draft.

[12] On December 6, 2019, while on injured reserve, he was suspended four games for violating the NFL's substance-abuse policy.

Without Speaks, the Chiefs won Super Bowl LIV against the San Francisco 49ers.

[15] On October 2, 2020, Speaks was signed to the practice squad of the Las Vegas Raiders.

[23] On December 22, 2021, Speaks was signed to the Buffalo Bills practice squad, but was released five days later.

[24][25] On December 22, 2022, Speaks signed with the Michigan Panthers of the United States Football League (USFL).

[26] In his Panthers debut, Speaks produced three sacks, seven combined tackles, and one forced fumble.