Brodifacoum

[2] Brodifacoum has an especially long half-life in the body, which ranges up to nine months, requiring prolonged treatment with antidotal vitamin K for both human and pet poisonings.

[3] Significant experience in brodifacoum poisonings has been gained in many human cases where it has been used in attempted suicides, necessitating long periods of vitamin K treatment.

In March 2018, cases of severe coagulopathy and bleeding associated with synthetic cannabinoid use contaminated with brodifacoum were reported in five states of the US.

This is done using KOH and EtOH for hydrolysis, and then adding SOCl2 for chlorination to form the acid chloride which reacts with the addition of lithium anion.

Typically, a Friedel-Crafts type cyclization would then be used to obtain the two-ring system portion of Compound 4, but this results in low yield.

However, due to very high potency and long duration of action (elimination half-life of 20 – 130 days), it is characterised as a "second-generation" or "superwarfarin" anticoagulant.

A poisoned animal suffers progressively worsening internal bleeding, leading to shock, loss of consciousness, and eventually death.

[17] Biological resistance to brodifacoum has been indicated in some species of rats in sample studies [18] Brodifacoum is marketed under many trade names, including Arakus (Advansia), Biosnap, d-CON, Finale, Fologorat, Havoc, Jaguar, Klerat, Matikus, Mouser, Pestoff, Rakan, Ratak+, Rataquill Colombia, Ratshot Red, Rattex, Rodend, Rodenthor, Ratsak, Talon,[19] Volak, Vertox, and Volid.

In one report, a woman deliberately consumed over 1.5 kg (3 lb) of rat bait, constituting about 75 mg brodifacoum, but made a full recovery after receiving conventional medical treatment.

Computed tomography scan of the abdomen demonstrated transmural hematoma, and a fecal occult blood test was positive.

The patient was hospitalized and successfully treated with fresh frozen plasma, cryoprecipitate, and vitamin K. In conclusion, paradoxical thrombosis and hemorrhage should raise the suspicion for superwarfarin toxicity in the appropriate clinical setting.

Concomitant presentation for thrombosis and hemorrhage with remarkably abnormal PT and PTT should raise the suspicion for brodifacoum poisoning.

A sample was analyzed and tested positive for brodifacoum; the NYC Department of Correction stated it was investigating the incident.

Products named Matrix and Blue Giant from a convenience store in Chicago have tested positive for brodifacoum and AMB-FUBINACA (FUB-AMB).

Stereospecific formation of Brodifacoum using an asymmetric organocopper compound.
Notice about laying of brodifacoum baits in New Zealand
Baitbox containing brodifacoum in Finland