The Southern Pacific Railroad served the Byron Hot Springs depot, with seven stops per day.

[3] Around 1878 a 10-page brochure was published advertising the hot springs and their "curative waters" as "preeminently the natural sanitarium of California and the Pacific Coast.

In 1912, the entire wood-framed property burned to a "mass of ashes", and the final hotel was built from concrete and fireproof brick.

The resort amenities provided soaks in the mineral water and mudbaths which were claimed to relieve various ailments including neuritis and rheumatism.

[5] The property was then bought and sold several times, serving as a resort, country club, and private residence.

[3] In 1956, the Oakland Tribune reported that plans were in the works for the "famed mecca for tourists and mineral bath devotees" to revive the resort after having been repurposed during WWII by the military and later the Greek Orthodox Church.

The proposed renovation would restore the hotel, mud baths, indoor and outdoor warm mineral water swimming pools, a nine-hole golf course, and other amenities.