1DS5, 1JWH, 1QF8, 3EED, 4DGL, 4MD7, 4MD8, 4MD9, 4NH1, 2R6M146013001ENSG00000230700ENSG00000224398ENSMUSG00000024387P67870P67871NM_001320NM_001282385NM_009975NM_001303445NM_001303446NM_001303476NP_001269314NP_001311NP_001290374NP_001290375NP_001290405NP_034105Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene.

[5][6] It is a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication.

The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, and a potential metal-binding motif.

[10] The beta subunit is a highly conserved protein of about 25kDa that contains, in its central section, a cysteine-rich motif, CX(n)C, that could be involved in binding a metal such as zinc.

[11] The mammalian beta-subunit gene promoter shares common features with those of other mammalian protein kinases and is closely related to the promoter of the regulatory subunit of cAMP-dependent protein kinase.