Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.

This gene encodes a ribosomal protein that is a component of the 60S subunit.

The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes.

The protein interacts specifically with the beta subunit of casein kinase 2.

Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found.