Canindeyú (Spanish pronunciation: [kanindeˈʝu]) is a department in Paraguay.

The capital is the city of Salto del Guairá.

[1] Canindeyú comes from the Guarani words Kaninde - macaw; ju - yellow, blue-and-yellow macaw (Ara ararauna).

The department is divided in 16 districts: The eastern part of Canindeyu is very green; mostly rolling hills and soy bean farms.

A fair portion of the population consists of Brazilian immigrants.