Cantalupo Ligure is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 110 kilometres (68 mi) southeast of Turin and about 40 kilometres (25 mi) southeast of Alessandria.

Cantalupo Ligure borders the following municipalities: Albera Ligure, Borghetto di Borbera, Dernice, Montacuto, Roccaforte Ligure, and Rocchetta Ligure. }

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