Carlisle is a town in northern Schoharie County, New York, United States.

Civil War Medal of Honor recipient John Snyders Kenyon was born on May 5, 1843, in Grovenor Corners.

The northern town line is the border of Montgomery County, southwest of Amsterdam.

New York State Route 162 crosses the northeastern corner of Carlisle.

18.0% of all households were made up of individuals, and 6.5% had someone living alone who was 65 years of age or older.