Esperance is a village in Schoharie County, New York, United States.

The village was settled circa 1793, based on an original land grant, the Ten Eyck Patent of 1769.

The village is adjacent to the Schoharie Creek and is located on U.S. Route 20 at the junction of County Roads 28 and 44.

The racial makeup of the village was 96.84% White, 1.58% Black or African American, 1.05% Asian, and 0.53% from two or more races.

21.5% of all households were made up of individuals, and 8.1% had someone living alone who was 65 years of age or older.