Nocetum in 972 is confirmed to the Abbey of Saint Colombanus di Bobbio by Emperor Otto I, who in the same year in a donation to the monastery of San Pietro in Ciel d'Oro in Pavia mentioned Casale.

[4] In 1373 it was completely destroyed by the troops of Giovanni Acuto, and then rebuilt in its current position by order of Galeazzo Visconti, Duke of Milan.

[5] In 1707, following the accusation of partisanship against Philip V, were seized all assets to Spinola, including Casalnoceto, which will return in possession from 1725[6] to 1797, the year of suppression of the feuds.

Opposite the church of San Rocco is one of the most remarkable buildings in the town, now part of the Vaccari estate and used as a venue for events: the manor wing of this building (commissioned by Paolo Spinola in 1687, designed by the architect Giuseppe Quadrio and adapted as a summer residence by the Vaccari family and its descendants) was home to cloistered nuns belonging to the Carmelite order for about a century.

Some of the rooms contain period religious frescoes by the aforementioned Tavarone and furnishings, testifying to a way of life that is renewed on a daily basis with the presence of guests.